Cardiovascular Disease

Hyperlipidemia in Older Adults

Case Vignette

An 87-year-old man with well-controlled hypertension and no known cardiovascular disease had his cholesterol checked at a local health fair. He comes to the physician’s office with the following results: total cholesterol 245 mg/dL, triglycerides 141 mg/dL, high-density lipoprotein cholesterol (HDL-C) 57 mg/dL, and low-density lipoprotein cholesterol (LDL-C) 160 mg/dL. He is very functional and active, with no symptoms of angina or heart failure. How should this patient be managed?

Introduction

The National Cholesterol Education Program (NCEP)



Cardiovascular Disease in Elderly Women

Coronary Artery Disease

Coronary artery disease (CAD) increases with age in women and is the most common cause of death in elderly women. The prevalence of CAD is similar in elderly women and men. In one prospective study, CAD was present in 1010 of 2464 women (41%; mean age, 81 yr).1 At 46-month follow-up in this study, new coronary events (myocardial infarction or sudden cardiac death) occurred in 1086 of the 2464 women (44%) older than age 60 years.1

CAD is diagnosed if there is either coronary angiographic evidence of significant CAD, a documented myocardial infarction, a ty



Treating Systemic Hypertension in Older Persons

Author Affiliations:

From the Department of Medicine, Cardiology Division, New York Medical College/Westchester Medical Center, Valhalla, NY.

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Introduction

Hypertension in older persons is a major risk factor for coronary events,1-3 for stroke,1,4-6 for congestive heart failure (CHF),1,7,8 and for peripheral arterial disease.9-12 Older persons are more likely to have hypertension and isolated systolic hypertension, to have target organ damage and clinical cardiovascular disease, and to develop new cardiovascular events, and are less l



Use of Digitalis in Older Adults: A Recent Update

Plants of the genus Digitalis are the source of digoxin. Historical evidence of pharmacological use of purple foxglove (Digitalis purpurea) is documented as early as 1250, when it was used as a recipe for headache. Its topical form was used in 1466 for wound healing. In 1785, Dr. William Withering, an English physician and botanist, analyzed approximately 200 cases, mostly with “dropsy” in his An Account of the Foxglove and Some of its Medical Uses: With Pract



Using C-Reactive Protein to Predict Cardiovascular Risk in Older Patients

One of the major health concerns for older persons is their potential risk for serious cardiovascular events, a risk that rises dramatically with increasing age.11,2 For example, the average annual rate of first major cardiovascular events rises from 7 per 1000 men at ages 35-44 years to 68 per 1000 men at ages 85-94; comparable rates occur in women 10 years later in life.3

Coronary heart disease (CHD) is more prevalent in the elderly, with over 83% of cardiovascular disease deaths in the United States occurring in individuals age 65 years or older.4 Indiv



Effects of Antihypertensive Drug Treatment on Cognitive Function and the Risk of Dementia

INTRODUCTION
Hypertension has been associated with an increased risk of stroke, vascular dementia, and Alzheimer’s disease.1-10 Cerebral infarcts, lacunae, and white matter changes are implicated in the pathogenesis of vascular dementia, but also may lead to the development of Alzheimer’s disease.11 Microcirculatory disorders and endothelial dysfunction also may cause a deterioration in cognitive function in persons with hypertension.11 The Epidemiology of Vascular Aging study showed that hypertension is a major risk factor for severe white matter hyperin



Infective Endocarditis in Older Adults

CASE PRESENTATION
A 62-year-old functional but cachectic male, who was able to ambulate with a walker, presented to the emergency department (ED) with a temperature of 102.3 degrees F, and neck and low back pain. The patient reported having had subjective fever and chills at home starting 1 week prior to the hospital visit. He also reported generalized fatigue, occasional shortness of breath, and a 20-pound weight loss over 2 weeks. There were no reported changes in mental status. The patient did have a recent history of having had a left carotid sinus takedown with removal of the optic nerve



Lipid-Lowering Medications in the Elderly

CME ARTICLE
ACCREDITATION
The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The Johns Hopkins University School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.

CREDIT DESIGNATION STATEMENT
The Johns Hopkins University School of Medicine designates this educational activity for a maximum of 1.0 category 1 credit toward the AMA Physician’s Recognition Award. Each physician should claim only those hours



CME Article: Peripheral Arterial Disease and the Older Adult: More Sinister than It Appears

ACCREDITATION
The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The Johns Hopkins University School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.

CREDIT DESIGNATION STATEMENT
The Johns Hopkins University School of Medicine designates this educational activity for a maximum of 1.0 category 1 credit toward the AMA Physician’s Recognition Award. Each physician should claim only those hours of credit th



Treatment of Older Persons with Hypertension

Older persons are more likely to have hypertension and isolated systolic hypertension. They are also more likely to have target organ damage and clinical cardiovascular disease, and to develop cardiovascular events. Finally, the reality is that they are also less likely to have their hypertension controlled. Consequently, the need for antihypertensive treatment in this patient population remains crucial. The use of such drug therapy results in a reduction of coronary events, stroke, and heart failure in older persons.

This article examines the evidence supporting the incidence and prevalen