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Anticholinergic Therapy for OAB: Cognitive Implications for an At-Risk Geriatric Population
Gary G. Kay, PhDIntroduction
Overactive bladder (OAB) is a common condition that affects millions of Americans and increases in incidence with age. The primary pharmacologic treatment for OAB is therapy with antimuscarinic agents. The cholinergic system through which these agents elicit their therapeutic efficacy, however, is also critical to normal cognitive function. The nucleus basalis and medial septal nucleus provide the brain’s primary cholinergic supply, extensively innervating the neo
