Supplement to Clinical Geritrics: Appropriate Management of OAB: Optimizing Safety in the Geriatric Patient

Anticholinergic Therapy for OAB: Cognitive Implications for an At-Risk Geriatric Population
Gary G. Kay, PhD
Introduction
Overactive bladder (OAB) is a common condition that affects millions of Americans and increases in incidence with age. The primary pharmacologic treatment for OAB is therapy with antimuscarinic agents. The cholinergic system through which these agents elicit their therapeutic efficacy, however, is also critical to normal cognitive function. The nucleus basalis and medial septal nucleus provide the brain’s primary cholinergic supply, extensively innerv...