Diabetes Mellitus: Present and Future Preventive Strategies—Part II
Prevention of type 2 diabetes mellitus at a preclinical phase with pharmacologic treatment has been gaining interest. Medications that have been proposed include acarbose, metformin, orlistat, antihypertensives, and the thiazolidinediones (TZDs). The pharmacologic prevention of complications of diabetes using pharmacologic means, or tertiary prevention, is beyond the scope of this discussion.
The Study TO Prevent Non–Insulin-Dependent Diabetes Mellitus (STOP-NIDDM) is a double-blind, placebo-controlled, randomized trial with an intention-to-treat analysis evaluating high-risk pers...
