Constipation in the Older Adult
- Thu, 1/17/08 - 4:16am
- 0 Comments
- 6312 reads
Pages 44 - 54
Accreditation
The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The Johns Hopkins University School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.
Credit Designation Statement
The Johns Hopkins University School of Medicine designates this educational activity for a maximum of 1.0 category 1 credit toward the AMA Physician’s Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the educational activity. Valid December 1, 2004 - February 28, 2005. Estimated time: 1 hour
FULL DISCLOSURE POLICY AFFECTING CME ACTIVITIES
As a provider accredited by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of Johns Hopkins University School of Medicine to require the disclosure of the existence of any significant financial interest or any other relationship a faculty member or provider has with the manufacturer(s) of any commercial product(s) discussed in an educational presentation. The presenting faculty reported the following: Dr. Cole has indicated that he has not received financial support for consultation, research or evaluation or has a financial interest relevant to this article. Dr. Lacy has indicated that he has received grants/research support from Novartis Phamaceuticals, AstraZeneca, and GlaxoSmithKline. No faculty member has indicated that their presentation will include information on off-label products.
DISCLAIMER STATEMENT
The opinions and recommendations expressed by faculty and other experts whose input is included in this program are their own. This enduring material is produced for educational purposes only. Use of Johns Hopkins University School of Medicine name implies review of educational format design and approach. Please review the complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.
Educational Objectives
1. To understand the prevalence and natural history of chronic constipation in the older patient
2. To review the current definition of constipation and understand differences in patient and physician perceptions of this disorder
3. To review the common etiologies and the underlying patho- physiologies of constipation in the older patient
4. To review current treatment options using an evidence-based approach
Constipation is a heterogeneous disorder with a wide spectrum of symptoms and complaints. Constipation results in 2.5 million office visits each year,1 leads to a significant reduction in quality of life,2 and is expensive to treat.3,4 This review describes the difficulties in defining constipation in clinical practice, the epidemiology and natural history of constipation in the older adult, normal and abnormal colonic physiology, the effects of aging on the colon, and provides recommendations on cost-effective methods of evaluating and treating this common disorder.
Definition
Physicians and patients differ dramatically in their definition of constipation. Clearly defining what is meant by the term constipation is critical to accurately diagnose the problem, review the natural history, and assess response to treatment. Physicians tend to use objective measures to define constipation, and this typically involves measuring stool frequency. Several large population studies have shown that most individuals have from 3 bowel movements per day to 3 bowel movements per week.5,6 As such, many physicians define constipation as less than 3 bowel movements per week.
References
1. Sonnenberg A, Koch TR. Epidemiology of constipation in the United States. Dis Colon Rectum 1989;32:1-8.
2. Irvine EJ, Ferrazzi S, Pare P, et al. Health-related quality of life in functional GI disorders: Focus on constipation and resource utilization. Am J Gastroenterol 2002;97:1986-1993.
3. Borum ML. Constipation: Evaluation and management. Prim Care 2001;28:577-590.
4. Rantis PC, Vernava AM III, Daniel GL, Longo WE. Chronic constipation– Is the work-up worth the cost? Dis Colon Rectum 1997;40: 280-286.
5. Connell AM, Hilton C, Irvine G, et al. Variation in bowel habits in two population samples. Br Med J 1965;5470:1095-1099.
6. Drossman DA, Sandler RS, McKee DC, Lovitz AJ. Bowel patterns among subjects not seeking health care. Use of a questionnaire to identify a population with bowel dysfunction. Gastroenterology 1982;83:529-534.
7. Herz MJ, Kahan E, Zalevski S, et al. Constipation: A different entity for patients and doctors. Fam Prac 1996;13:156-159.
8. Sandler RS, Drossman DA. Bowel habits in young adults not seeking health care. Dig Dis Sci 1987;32:841-845.
9. Drossman DA, Corazziaria E, Talley NJ, et al, eds. ROME II. The Functional Gastrointestinal Disorders. McLean, VA: Degnon, 2000:351-432.
10. Stewart WF, Liberman JN, Sandler RS, et al. Epidemiology of constipation (EPOC) study in the United States: Relation of clinical subtypes to sociodemographic features. Am J Gastroenterol 1999;94: 3530-3540.
11. Harari D, Gurwitz JH, Avorn J, et al. Bowel habit in relation to age and gender: Findings from the National Health Interview Survey and clinical implications. Arch Intern Med 1996;156: 315-320.
12. Talley NJ, Fleming KC, Evans JM, et al. Constipation in an elderly community: A study of prevalence and potential risk factors. Am J Gastroenterol 1996;91:19-25.
13. Whitehead WE, Drinkwater D, Cheskin LJ, et al. Constipation in the elderly living at home. Definition, prevalence, and relationship to lifestyle and health status. J Am Geriatr Soc 1989;37:423-429.
14. Johanson JF, Sonnenberg A, Koch TR. Clinical epidemiology of chronic constipation. J Clin Gastroenterol 1989;11:525-536.
15. Hale WE, Perkins LL, May FE, et al. Symptom prevalence in the elderly. An evaluation of age, sex, disease, and medication use. J Am Geriatr Soc 1986;34:333-340.
16. Pare P, Ferrazzi S, Thompson WG, et al. An epidemiological survey of constipation in Canada: Definitions, rates, demographics, and predictors of health care seeking. Am J Gastroenterol 2001;96: 3130-3137.
17. Higgins PD, Johanson JF. Epidemiology of constipation in North America: A systematic review. Am J Gastroenterol 2004;99: 750-759.
18. Johanson JF. Geographic distribution of constipation in the United States. Am J Gastroenterol 1998;93: 188-191.
19. Bassotti G, Gaburri M. Manometric investigation of high amplitude propagated contractile activity of the human colon. Am J Physiol 1988;255:G660-664.
20. Rao SS, Sadeghi P, Batterson K, Beaty J. Altered periodic rectal motor activity: A mechanism for slow-transit constipation. Neurogastroenterol Motil 2001;13: 591-598.
21. He C-L, Burgart L, Wang L, et al. Decreased interstitial cell of Cajal volume in patients with slow transit constipation. Gastroenterology 2000;118:14-21.
22. Yu S, Crowell MD, Tihan T, Lacy BE. Distribution of interstitial cells of Cajal in the whole colon from patients with slow-transit constipation. Am J Gastroenterol 2002;97:S118.
23. Melkersson M, Andersson H, Bosaeus I, Falkhenden I. Intestinal transit time in constipated and non-constipated geriatric patients. Scand J Gastroenterol 1983;18:593-597.
24. Metcalf AM, Phillips SF, Zinsmeister AR, et al. Simplified assessment of segmental colonic transit. Gastroenterology 1987;92:40-47.
25. McKay LF, Smith RG, Eastwood MA, et al. An investigation of colonic function in the elderly. Age Ageing 1983;12:105-110.
26. Bannister JJ, Abouzekry L, Read NW. Effect of aging on anorectal function. Gut 1987;28:353-357.
27. Varma JS, Bradnock J, Smith RG, Smith AN. Constipation in the elderly. A physiologic study. Dis Colon Rectum 1988;31:111-115.
28. Read NW, Abouzekry L, Read MG, et al. Anorectal function in elderly patients with fecal impaction. Gastroenterology 1985;89:959-966.
29. Laurberg S, Swash M. Effects of aging on the anorectal sphincters and their innervation. Dis Colon Rectum 1989;32:737-742.
30. Ruben BD. Public perceptions of digestive health and disease. Survey findings and communications implications. Pract Gastroenterol 1986;10:35-42.
31. Burkitt DP, Walker ARP, Painter NS. Dietary fiber and disease. JAMA 1974;229: 1068-1074.
32. Burkitt DP, Walker ARP, Painter NS. Effect of dietary fibre on stools and transit times, and its role in the causation of disease. Lancet 1972;ii:1408-1412.
33. Hull C, Greco RS, Brooks DL. Alleviation of constipation in the elderly by dietary fiber supplementation. J Am Geriatr Soc 1980;28: 410-414.
34. Finlay M. The use of dietary fibre in a long-stay geriatric ward. J Nutr Elderly 1988;8:19-30.
35. Cheskin LJ, Kamal N, Crowell MD, et al. Mechanisms of constipation in older persons and effects of fiber compared with placebo. J Am Geriatr Soc 1995;43:666-669.
36. Hyland CM, Foran JD. Dioctyl sodium sulphosuccinate as a laxative in the elderly. Practitioner 1968;200:698-699.
37. Fain AM, Susat R, Herring M, Dorton K. Treatment of constipation in geriatric and chronically ill patients: A comparison. South Med J 1978;71:677-680.
38. Wesselius-deCasparis A, Braadbaart S, Bergh-Bohlken GE, Mimica M. Treatment of chronic constipation with lactulose syrup-results of a double-blind study. Gut 1968;9:84-86.
39. Sanders JF. Lactulose syrup assessed in a double-blind study of elderly constipated patients. J Am Geriatr Soc 1978;26:236-239.
40. Vanderdonckt J, Coulon J, Denys W, Ravelli GP. Study of the laxative effect of lactitol (Importal-R) in an elderly institutionalized, but not bedridden, population suffering from chronic constipation. J Clin Experim Gerontology 1990;12:171-190.
41. Lederle FA, Busch DL, Mattox KM, et al. Cost-effective treatment of constipation in the elderly: A randomized double-blind comparison of sorbitol and lactulose. Am J Med 1990;89:597-601.
42. Kinnunen O, Winblad I, Koistinen P, Salokannel J. Safety and efficacy of a bulk laxative containing senna versus lactulose in the treatment of chronic constipation in geriatric patients. Pharmacology 1993;47(Suppl 1):253-255.
43. Passmore AP, Davies KW, Flanagan PG, et al. A comparison of Agiolax and lactulose in elderly patients with chronic constipation. Pharmacology 1993;47(Suppl 1):249-252.
44. Smith B. Pathologic changes in the colon produced by anthraquinone purgatives. Dis Colon Rectum 1973;16:455-458.
45. Kiernan JA, Heinicke EA. Sennosides do not kill myenteric neurons in the colon of the rat or mouse. Neuroscience 1989;30:837-842.
46. Lacy BE, Yu S. Tegaserod: A new 5-HT4 agonist. J Clin Gastroenterol 2002;34: 27-33.
47. Tramonte SM, Brand MB, Mulrow CD, et al. The treatment of chronic constipation in adults-A systematic review. J Gen Intern Med 1997;12: 15-24.







